Many cholinergic drugs have been used in the analysis of specific mutants and behaviors; however, the two that have had the most significant impact on C. elegans neurobiology are aldicarb and levamisole.
Using WMicrotracker, it is possible to easy quantify the effect and kinetic of acetylcholine channels modulators, as well as other neuronal channels involved in behavior. Below we present an example of application.
In these experiments we can observe the kinetic and dose response to two Acetylcholine channels modulators: Aldicarb and Levamisole. In less than one hour a quantitative dose response effect is obtained.