Zebrafish (Danio rerio) is increasingly being employed for evaluating toxicity and drug discovery assays. Global swimming behavior could be a simple readout for toxicity, easy to scale-up in automated experiments. This approach is potentially applicable for fast ecotoxicity assays and whole-organism high-throughput compound screening, reducing the time and money required to evaluate unknown samples and to identify leading pharmaceutical compounds.
Fish toxicity measures are easily implemented using our WMicrotracker system. Below you'll find a procedure example.
In this experiment we can observe the effect of EtOH on zebrafish’s larvae behavior after 48h of drug exposure. The plot shows the average activity and the natural variability of response between animals (n = 16 per treatment).