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The wMicroTracker One instrument can be used to measure the locomotor activity of parasitic nematodes cultured in liquid media and in multi-well plates.

The conventional methods of measuring anthelmintic efficiency on parasitic nematode are laborious and low throughput. The wMicroTracker instrument can be used for library screening and drug discovery in a variety of parasitic nematodes.

The wMicroTracker ONE has been tested and validated for the following parasitic species:

Species Stage Lenght in µm
Echinococcus granulosus protoscolex 200
Mesocestoides corti tetrathyridia 750-1000
Haemonchus contortus L3 730-805
Cooperia oncophora xL3 865-940
Teladorsagia circumcincta xL3 830-865
Ostertagia ostertagi xL3 850-915
Dirofilaria immitis larvae 300
Brugia pahangi microfilariae/ L3 177-230 / 1000-2000
Schitosoma mansoni schistosomules 110
Meloidogyne incognita J2 350-450

  1. The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs. Hugo R Vaca, Ana M Celentano, María A Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira , María C Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit. PLoS Negl Trop Dis. Mar 2021.
  2. In vitro screening methods for parasites: the wMicroTracker & the WormAssay. Emma Gunderson, Christina Bulman, Mona Luo, Judy Sakanari. microPublication Biology. July 2020.
  3. Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites. Liu M., Landuyt B., Klaassen H., Geldhof P., Luyten W. Veterinary Parasitology. 2018 Dec.
  4. Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. Rosenzvit MC et al. PLoS Negl Trop Dis. Feb 2018.
  5. The nervous and prenervous roles of serotonin in Echinococcus spp. Camicia F, Herz M, Prada LC, Kamenetzky L, Simonetta SH, Cucher MA, Bianchi JI, Fernández C, Brehm K, Rosenzvit MC. Int J Parasitol. Jul 2013.